Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice
Identifieur interne : 001C26 ( Main/Exploration ); précédent : 001C25; suivant : 001C27Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice
Auteurs : Eun Kim [États-Unis] ; Kaori Okada [États-Unis] ; Tom Kenniston [États-Unis] ; V. Stalin Raj [Pays-Bas] ; Mohd M. Alhajri [Qatar] ; Elmoubasher A. B. A. Farag [Qatar] ; Farhoud Alhajri [Qatar] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Andrea Gambotto [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- KwdFr :
- Adenoviridae, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cellules HEK293, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline G (sang), Infections à coronavirus (), Production d'anticorps, Souris de lignée BALB C, Tests de neutralisation, Vaccins antiviraux (immunologie).
- MESH :
- immunologie : Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- sang : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- Adenoviridae, Animaux, Cellules HEK293, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus, Production d'anticorps, Souris de lignée BALB C, Tests de neutralisation.
English descriptors
- KwdEn :
- Adenoviridae, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antibody Formation, Camelus, Coronavirus Infections (prevention & control), HEK293 Cells, Humans, Immunoglobulin G (blood), Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests, Spike Glycoprotein, Coronavirus (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Spike Glycoprotein, Coronavirus, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Adenoviridae, Animals, Antibody Formation, Camelus, HEK293 Cells, Humans, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests.
Abstract
A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans.
Url:
DOI: 10.1016/j.vaccine.2014.08.058
PubMed: 25192975
PubMed Central: 7115510
Affiliations:
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Le document en format XML
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Stalin" last="Raj">V. Stalin Raj</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M." last="Alhajri">Mohd M. Alhajri</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Animal Resources Department – Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department – Ministry of Environment, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name><affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Antibody Formation</term><term>Camelus</term><term>Coronavirus Infections (prevention & control)</term><term>HEK293 Cells</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Neutralization Tests</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Cellules HEK293</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Infections à coronavirus ()</term><term>Production d'anticorps</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Vaccins antiviraux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adenoviridae</term><term>Animals</term><term>Antibody Formation</term><term>Camelus</term><term>HEK293 Cells</term><term>Humans</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Neutralization Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adenoviridae</term><term>Animaux</term><term>Cellules HEK293</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Infections à coronavirus</term><term>Production d'anticorps</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. 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Vennema</name></author><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author><author><name sortKey="Harbour, D A" uniqKey="Harbour D">D.A. Harbour</name></author><author><name sortKey="Dalderup, M" uniqKey="Dalderup M">M. Dalderup</name></author><author><name sortKey="Gruffydd Jones, T" uniqKey="Gruffydd Jones T">T. Gruffydd-Jones</name></author><author><name sortKey="Horzinek, M C" uniqKey="Horzinek M">M.C. Horzinek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, R C" uniqKey="Weiss R">R.C. Weiss</name></author><author><name sortKey="Scott, F W" uniqKey="Scott F">F.W. Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C. Wohlford-Lenane</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S.S. Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C. Fett</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li><li>Qatar</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Pennsylvanie</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Kim, Eun" sort="Kim, Eun" uniqKey="Kim E" first="Eun" last="Kim">Eun Kim</name></region><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name><name sortKey="Kenniston, Tom" sort="Kenniston, Tom" uniqKey="Kenniston T" first="Tom" last="Kenniston">Tom Kenniston</name><name sortKey="Okada, Kaori" sort="Okada, Kaori" uniqKey="Okada K" first="Kaori" last="Okada">Kaori Okada</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name></region><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></country><country name="Qatar"><noRegion><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M." last="Alhajri">Mohd M. Alhajri</name></noRegion><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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